Stockholm3 study is named the best scientific publication by the European Association of Urology
July 5, 2022
Associate Professor Tobias Nordström is awarded the European Association of Urology (EAU) "Prostate Cancer Research Award 2022". He receives the award for the study STHLM3-MRI, which shows that Stockholm3, combined with magnetic camera examination (MRI), reduces the number of unnecessary biopsies by 76 percent in a general screening program. A follow-up health economic study also shows that Stockholm3 reduces the number of MRIs by 60 percent over the man's lifetime, which reduces cost and frees up resources.
“Stockholm3 is now available to healthcare providers throughout the EU. Receiving EAU's research award strengthens the interest in Stockholm3 and shows the great value of the test. The fact that Stockholm3 reduces magnetic camera examinations by 60 percent validates that the test is not only better than the standard PSA test, but also that it reduces the costs of care", says David Rosén, CEO of A3P Biomedical.
In 2021, the results of the STHLM3 MRI-study were published in The Lancet Oncology. The Lancet Editorial described the study as "an important step for smarter screening of prostate cancer". The article also won first prize for best oncological abstract at the EAU Congress in 2021. In early 2022, Professor Henrik Grönberg was awarded the "Cancer Researcher of the Year 2022" award by the Cancer Foundation for his world-leading research that enables early detection of prostate cancer. Henrik Grönberg and his team, which includes Tobias Nordström, at Karolinska Institutet have for many years conducted research in the prostate cancer area. This research has, among other things, resulted in Stockholm3, which has been successfully implemented in clinical use since 2017. Now Tobias Nordström also receives EAU's Prostate Cancer Research Award 2022.
Tobias Nordström is a urologist and researcher at Karolinska Institutet. He is one of Sweden's leading experts in prostate cancer. He is clinically active at Danderyd Hospital and the principal (PI) for the STHLM3 MRI study.
Publications
Prostate cancer screening using a combination of risk-prediction, magnetic resonance imaging and targeted prostate biopsies: results from the population-based STHLM3MRI trial. T. Nordström, A. Discacciati, M. Bergman, M. Clements, M. Aly, M. Annerstedt, A. Glaessgen, S. Carlsson, F. Jäderling, H. Grönberg, M. Eklund. The Lancet Oncology, online 12 augusti 2021, doi: 10.1016/ S1470-2045(21)00348-X.
Cost-effectiveness of Stockholm3 test and magnetic resonance imaging in prostate cancer screening: a microsimulation study. European Urology. https://doi.org/10.1016/j.eururo.2021.12.021. Hao, Shuang & Heintz, Emelie & Ostensson, Ellinor & Discacciati, Andrea & Jaderling, Fredrik & Gronberg, Henrik & Eklund, Martin & Nordström, Tobias & Clements, Mark. (2021).
About A3P Biomedical
A3P Biomedical is a company that specializes in advanced prostate cancer diagnostics. A3P’s main product, Stockholm3, is a clinically and commercially validated blood test for early detection and risk stratification of aggressive prostate cancer. A3P Biomedical is headquartered in Stockholm, Sweden. For more information, please visit www.a3p.com
About Stockholm3
Stockholm3 is a blood-based test, that runs a combination of protein biomarkers, genetic biomarkers and clinical information through an algorithm to find the probability of clinically significant cancer at biopsy.
Stockholm3 has been evaluated in clinical studies including more than 90,000 men. It is extensively tested in large population-based screening trials, as well as in real world clinical utility studies in primary care, as a reflex test to PSA at values 1.5-20 ng/ml. Benefits include the ability to reduce unnecessary MRIs, benign and Grade Group 1 prostate biopsies for men with elevated PSA, while simultaneously improving detection of clinically significant cancers in men with low or normal PSA values. Using Stockholm3 leads to a more accurate risk assessment than the current PSA standard. Stockholm3 detects 40-90% more men with aggressive prostate cancer and, at the same time, reduces over-detection by 40-50% compared to PSA.
Multiple Stockholm3 studies have been published in high-impact journals such as The Lancet Oncology, Journal of Clinical Oncology, and European Urology. The studies address both the specificity and sensitivity of Stockholm3 in multi-ethnic populations as well as health-economic benefits of implementing it in clinical care. For more information about our clinical studies please visit www.a3p.com.
About prostate cancer
Prostate cancer is the most common cancer in men. In 2020, the global incidence of new prostate cancer cases was 1.4 million, and prostate cancer specific mortality 370,000. Global prostate cancer incidence and mortality is expected to rise by 100% and 85% respectively by 2040, driven by an ageing population.
Press contact:
Cecilia Edström
cecilia.edstrom@a3p.com
+46 72 226 2328